Probiotics are favorable microorganisms that regulate the flora of the gastrointestinal system and stimulate the immune system. Lactobacillus reuteri was shown to reduce candida colonization. The objective of this study is to evaluate the efficacy of prophylactic Lactobacillus reuteri in reducing the candida colonization and infection in very low birth weight infants.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
300
Lactobacillus reuteri 100 million CFU/day for 3 months
50000 unit/3 times a day, both for orally and by orogastric route
Zekai Tahir Burak Maternity Teaching Hospital, Division of Neonatology
Ankara, Turkey (Türkiye)
Comparison of prophylactic Lactobacillus reuteri and nystatin on candida colonization and infection in very low birth weight infants
Rectal and skin swabs for Candida colonization will be taken weekly. Blood culture for Candida infection will be taken weekly.
Time frame: up to 6 months
Effect of Lactobacillus reuteri on feeding intolerance
Feeding intolerance (gastric residuals in the amount that was more than half of the previous feeding, abdominal distention or heme-positive stools)
Time frame: up to 6 months
Effect of Lactobacillus reuteri on sepsis
Patients with culture positivity will accept as proven sepsis.
Time frame: up to 6 months
Effect of Lactobacillus reuteri on length of hospital stay
Specified length of hospital stay as days.
Time frame: up to 6 months
Effect of Lactobacillus reuteri on necrotizing enterocolitis in VLBW infants
NEC diagnosis will make modified Bell's criteria. Grade 1A will not include in NEC group.
Time frame: up to 6 months
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