High Flow Nasal Cannula Versus Nasal Continuous Positive Airway Pressure

Christiana Care Health Services20 enrolled

Overview

The purpose of this study is to compare two common methods of providing respiratory support: nasal continuous airway pressure and high flow nasal cannula to see what effect it has on babies breathing. The investigators also will compare the effects of slightly changing the level of support these two different types of therapy on how easily your baby is breathing. Changes in the level of support and between these two respiratory support modalities are frequently done and are part of the routine care in the neonatal intensive care unit.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Respiratory Insufficiency

Interventions

Pulmonary Function Testing & esophageal pressure monitoringOTHER

Infants who are currently on NCPAP will have pulmonary function testing (PFTs)and esophageal pressure performed while on 2 different settings of NCPAP. These infants will then be transitioned HFNC and will undergo PFTs and esophageal pressure while on different HFNC settings. The infant will then be returned to NCPAP at the same settings they were on prior to any study interventions.

Pulmonary function testing and esophageal pressureOTHER

Infants who are currently on HFNC will have pulmonary function testing (PFTs) and esophageal pressure performed while on 2 different settings of HFNC. These infants will then be transitioned NCPAP and will undergo PFTs and esophageal pressure while on 2 different NCPAP settings. The infant will then be returned to HFNC at the same settings they were on prior to any study interventions.

Eligibility

Sex: ALLMin age: 2 DaysMax age: 6 MonthsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Infants who are between 28 and 40 weeks of corrected gestational age at the time of study entry * Currently on high flow nasal cannula receiving 3 to 5 lpm or on nasal continuous positive airway pressure at 5 to 6 cmH2P with and FiO2 requirement \</= 40% by the clinical care team for clinical care purposes. * On current mode of support for \>/= 12 hours and have been extubated from a mechanical ventilator for \>/= 48 hours. Exclusion Criteria: * Infants with skeletal or neuromuscular disorders that affect the accuracy of RIP PFT measurements.

Locations (1)

Christiana Care Health System - Christiana Hospital

Newark, Delaware, United States

Outcomes

Primary Outcomes

lung compliance

Is there a difference in pulmonary function tests in infants with respiratory insufficiency being treated with high flow nasal cannula (HFNC) or nasal continuous positive airway pressure (NCPAP)?

Time frame: 2 hours

Data from ClinicalTrials.gov

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