Effects of Hypercapnia on Emergence From General Anesthesia Under Propofol

DongGuk University30 enrolled

Overview

Hypercapnia derives increase of cerebral blood flow and cardiac output. It means that the rate of propofol elimination from the brain and the blood will be increased and the patient will awake more quickly. There has been no study about the effects of hypercapnia. The investigators will evaluate hypercapnia's effects on the recovery time from propofol anesthesia.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

DOUBLE

Enrollment

Conditions

Anesthesia, Intravenous Anesthesia Recovery Period

Interventions

Rebreathing tubePROCEDURE

750 ml rebreathing tube will be connected between the corrugated tube and the tracheal tube of a patient. Target partial pressure of the end-tidal carbon dioxide is 50 mmHg.

No rebreathing tube (Nothing)PROCEDURE

750 ml rebreathing tube will not be connected between the corrugated tube and the tracheal tube of a patient. Target partial pressure of the end-tidal carbon dioxide is 30 mmHg.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * American Society of Anesthesiologists physical status (ASA PS) I-II * Age 20 - 60 years male and female * Elective schedule with minor surgery under general anesthesia Exclusion Criteria: * Body mass index (BMI) \>= 30 (kg/m2) * Patient with pulmonary, cardiac, endocrinal, neuromuscular and neurological diseases or past history * Patient with medication affecting on this study * Patient with general anesthesia history within one month

Locations (1)

Dept. of anesthesiology and pain medicine, Dongguk University Ilsan Hospital

Goyang, Kyunggido, South Korea

Outcomes

Primary Outcomes

Time to open eyes under investigator's command

After stopping propofol infusion, every 30 seconds, the investigator (caregiver) will command the patient, "Open your eyes". When the patient opens eyes, the time will be recorded. The patients will be followed for an expected average of 10 minutes.

Time frame: From cessation of propofol infusion to patient's eye opening (seconds)

Secondary Outcomes

Time to breath spontaneously

The time from cessation of propofol infusion to patient's spontaneous breaths will be recorded. The patients will be followed for an expected average of 10 minutes.

Time frame: From cessation of propofol infusion to patient's spontaneous breathing (sec)

Change of bispectral index (BIS)

After stopping propofol infusion, the BIS and time (seconds) will be recorded and reviewed. These will be recorded for an expected average of 15 minutes.

Time frame: From the cessation of propofol infusion to extubation, BIS and time (seconds) will be recorded.

Time to open mouth under investigator's command

After the patient opens the eyes, every 10 seconds, the investigator command the patient, "Open your mouth.". When the patient opens mouth, the time will be recorded. The patients will be followed for an expected average of 12 minutes.

Time frame: From cessation of propofol infusion to patient's mouth opening (seconds)

Time to extubation

After stopping propofol infusion, When the patient breaths spontaneously with adequate tidal volume and respiratory rates, the trachea will be extubated and the time will be recorded. The patients will be followed for an expected average of 15 minutes.

Time frame: From cessation of propofol infusion to extubation (sec)

Data from ClinicalTrials.gov

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