A Study of Drug-Drug Interaction Between Danoprevir/Low-Dose Ritonavir and Raltegravir in Healthy Volunteers

Inclusion Criteria: * Healthy non-smoking male and female adults, 18 - 55 years of age, inclusive * Healthy status defined by absence of evidence of any active or chronic disease * Medical history without major, recent, or ongoing pathology * Weight \>/= 50.0 kg * Body mass index (BMI) 18.0 - 32-0 kg/m2 * Willingness to abstain from alcohol, xanthine-containing beverages or food (e.g. coffee, tea, cola, chocolate, "energy drinks") from 48 hours prior to entry in the clinical site until discharge * Females of child-bearing potential and males and their female partners of child-bearing potential must agree to use 2 forms of contraception, one of which must be a barrier method, during the study and for 90 days after the last drug administration. Acceptable barrier forms of contraception are condom and diaphragm; acceptable non-barrier forms of contraception for this study are non-hormonal intrauterine device (IUD) and/or spermicide Exclusion Criteria: * Pregnant or lactating females or males with female partners who are pregnant or lactating * Any history of clinically significant cardiovascular or cerebrovascular disease, hypertension, and/or infections * Positive test for drugs of abuse at screening or prior to admission to the clinical site during any study period * Positive for hepatitis B, hepatitis C or HIV infection * Current smokers or subjects who have discontinued smoking less than 6 months prior to first dose of study medication * Use of hormonal contraceptives within 30 days before the first dose of study medication * History of clinically significant drug-related allergy (such as anaphylaxis) or hepatotoxicity