Post-exercise Insulin Reductions in Type 1 Diabetes

Northumbria University13 enrolled

Overview

The investigators hypothesise that reducing rapid-acting insulin dose after exercise will help prevent Type 1 diabetes individuals experiencing hypoglycaemia.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Type 1 Diabetes

Interventions

Reducing post-exercise rapid-acting insulin (insulin lispro or aspart) doseOTHER

Dosage after exercise

Eligibility

Sex: MALEMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * T1DM, * Male, * basal-bolus regimen (insulin glargine / detemir with insulin lispro / aspart), * HbA1c \< 9.9%, * aged 18-50. Exclusion Criteria: * HbA1c \> 10%, * not treated with basal-bolus (insulin glargine / detemir with insulin lispro / aspart), * aged \<18 \> 50.

Locations (1)

Clinical Research Facility

Newcaslte Upon Tyne, Tyne and Wear, United Kingdom

Outcomes

Primary Outcomes

24 hour blood glucose area under the curve

24 hour, post-exercise, glucose area under the curve.

Time frame: 24 hours

Secondary Outcomes

Ketogenesis

Blood beta-hydroxybutyrate concentrations

Time frame: 60 minutes before and 24 hours post-exercise

Data from ClinicalTrials.gov

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