The Eshre Study Into The Evaluation of Oocyte Euploidy by Microarray Analysis

Inclusion Criteria: * infertility as an indication for IVF or ICSI; * patients between their 36th and 41st birthdays (at time of signing ICF i.e. max 40years and 364days at the day of signing the informed consent); * BMI range 18 to 30 kgs per m2; * patients prepared to accept transfer of up to two embryos; * absence of any type of genetic abnormality in the patient's personal and family history; * normal karyotype (optional) Exclusion Criteria: * treatment involving donor oocytes (donor sperm is allowed subject to local practice and regulations and provided karyotype of the sperm donor is available and normal); * menstrual irregularity (\<24 and \>35 days); * three or more previous failed IVF or ICSI cycles, with the present partner. (Definition of a failed cycle: 'absence of a clinical pregnancy relating to a treatment with embryo transfer resulting from oocyte retrieval for the current intended pregnancy and with the current partner; the transfers include transfers of fresh and frozen within this treatment; clinical pregnancy is defined as the presence of a gestational sac at the earliest ultrasound and includes early clinical miscarriage, late miscarriage and clinically confirmed extrauterine pregnancy, and excludes preclinical miscarriage (biochemical pregnancy); - * three or more clinical miscarriages; * poor response in any previous cycle; * low ovarian reserve (At least one of the following two features must be present: (1) a previous poor ovarian response (≤ 3 oocytes with a conventional stimulation 119 protocol); (2) an abnormal ovarian reserve test (i.e. AFC \< 5 follicles or AMH \< 0,5 ng/mL)\* (adapted from Ferraretti et al., 2011); * cycles requiring surgical sperm recovery procedures; * total asthenozoospermia and/or globozoospermia. * any type of genetic abnormality or family history of genetic abnormality in subject or partner