The Effect of Priming Intravenous Rocuronium on Fentanyl-Induced Coughing

Taichung Armed Forces General Hospital260 enrolled

Overview

An intravenous bolus of fentanyl often induces a cough reflex. This study investigates whether priming with rocuronium can attenuate fentanyl-induced coughing effectively.

Fentanyl is widely used for analgesia and anesthesia because of its rapid onset, its intense analgesic effect, and is associated with lessened cardiovascular depression and low histamine release. Although the cough reflex is usually transient and self-limiting, it should be avoided in situations such as elevated intracranial, intraocular, or intra-abdominal pressure, and unstable hemodynamics. The cause of FIC is unclear. One hypothesis is that vocal cord spasms might induce coughing because of fentanyl-induced muscle rigidity and histamine release. Muscle relaxants are commonly used to treat this condition. This study hypothesizes that priming muscle relaxants could prevent or suppress FIC. This study investigates whether the muscle relaxant rocuronium attenuates FIC effectively.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

260

Conditions

Fentanyl-induced Coughing

Interventions

RocuroniumDRUG

All patients were given oxygen via a face mask. The patients were then administered with the following medications intravenously: the rocuronium group received rocuronium 0.06 mg kg-1, and the control group received the same volume of normal saline 30 s before the injection of an IV fentanyl bolus (1.5 mcg kg-1, within 2 s).

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 260 ASA I-II patients, * aged between 18 and 80 years, and undergoing various elective surgeries at Taichung Armed Forces General Hospital. Exclusion Criteria: * a history of asthma, * chronic cough, * smoking, * upper respiratory tract infection in the previous 2 weeks, and * medication containing angiotensin-converting enzyme inhibitors or anesthetic premedication.

Locations (1)

Taichung Armed Forces General Hospital

Taichung, Taiwan

Outcomes

Primary Outcomes

Incidence of fentanyl-induced coughing

Following the fentanyl injection, another anesthetist who was blind to the pretreatment recorded the number of coughs for 1 min. The severity of coughing was graded as mild (1-2 times), moderate (3-5 times), or severe (\> 5 times) based on the number of coughs within the 1 min following the fentanyl injection. Assisted mask ventilation with oxygen was supplied if desaturation occurred (SpO2 \< 90%).

Time frame: 2 minutes

Data from ClinicalTrials.gov

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