The study searched for answers to two questions 1. What is the effect of testosterone replacement therapy on endothelial dysfunction, inflammation and insulin resistance? 2. Regarding the above parameters, is there any difference between daily transdermal testosterone implementation and intramuscular injection performed in three weeks.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
106
50mg testosterone gel implementation on every night
The testosterone 250mg ester IM injections performed in three weeks.
Gulhane School of Medicine Department of Endocrinology and Metabolism
Ankara, Non US, Turkey (Türkiye)
The alterations in the measures for endothelial functions
The alterations in Endothelial functions are determined by measuring plazma ADMA levels, as a surrogate. ADMA measurement is pereformed by ELISA kit (Immundiagnotik, Bensheim, Germany)(Catalog Number 7828) with a minimal detection limit of 0.05µmol/L.
Time frame: 6 months
The alterations in the measures of insulin resistance
The alterations in insulin sensitivity are estimated by using the HOMA index by the formula, HOMA-IR = (insulin x glucose)/405.
Time frame: 6 months
The alterations in the measures of inflammation
The alterations in the measures of inflammation are determined by measuring Human Pentraxin-3 levels. ELISA kiti /R\&D Systems, Inc. Minneapolis, MN, ABD) (Catalog number DPTX30) with a minimal detection limit of 0.025ng/ml, intraassay CV of 3.8-4.4%, and interassay CV of 4.1-6.1% was used.
Time frame: 6 months
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