The aim of this study is to determine the effect of epinephrine on systemic absorption of local anaesthetic mepivacaine administered for brachial plexus block in uremic patients scheduled for creation or repair of an arteriovenous fistula. Furthermore, an impact of epinephrine on the central circulation and peripheral tissue oxygenation will be evaluated.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
16
Ultrasound-guided infraclavicular brachial plexus block with mepivacaine 400 mg (10 mg/mL) mixed with epinephrine 200 μg (5 μg/mL)
Ultrasound-guided infraclavicular brachial plexus block with plain mepivacaine 400 mg (10 mg/mL)
Rigshospitalet
Copenhagen, Denmark
Plasma concentration of mepivacaine
Time frame: 0, 5, 10, 20, 30, 45, 60, 120, and 180 min after blockade
Central circulation
Heart rate, blood pressure, cardiac output, stroke volume, and systemic vascular resistance
Time frame: 0, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, and 60 min after blockade
Peripheral tissue oxygenation
Near infrared spectrometry obtained from the triceps muscle of the blocked arm
Time frame: 0, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, and 60 min after blockade
Cardiotoxicity of local anesthetic
12-lead ECG
Time frame: 0, 5, 10, 20, 30, 45, and 60 min after blockade
Neurotoxicity of local anesthetic
Visual and hearing disturbances, dysarthria, tingling, perioral numbness, dizziness, paraesthesia, muscular twitching and rigidity
Time frame: Continuously for 1 hour after blockade
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