Objectives The CATCH trial (CArdiac cT in the treatment of acute CHest pain) is a prospective randomized controlled trial designed to evaluate the clinical value of cardiac multidetector computed tomography (MDCT) as a first-line diagnostic strategy in patients with acute chest pain, compared to a conventional functional-based testing strategy. Methods: Consecutive patients admitted with acute chest pain of suspected cardiac origin, but normal electrocardiogram and biomarkers were randomized to evaluation with 320-MDCT coronary angiography (CT-guided group) or with standard bicycle exercise test and/or myocardial perfusion imaging - MPI (Control group). After one year, patients will be followed-up, with registration of clinical endpoints such as Cardiac death, myocardial infarction, need for revascularisation, admittance for heart related problems, sustained chest pain, live quality score, use of medication.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
600
Patients will (on top of the standard clinical evaluation with a functional-based stress-test) be examined with a Cardiac CT scan. In the control group, the Cardiac CT will be blinded for clinical evaluation and only used retrospectively for research purpose.
Hvidovre University Hospital
Hvidovre, Denmark
combined endpoint of: Cardiac death, myocardial infarction, unstabile angina, revascularisation, readmissions for chest pain
Time frame: 1 year follow-up
Cardiac death
Time frame: 1 year follow-up
myocardial infarction
Time frame: 1 year follow-up
readmissions for chest pain
Time frame: 1 year follow-up
Revascularisation
Time frame: 1 year follow-up
unstabile angina
Time frame: 1-year follow-up
continued chest pain
Time frame: 1 year follow-up
Quality of life (SF-36)
Time frame: 1-year follow-up
medication
Time frame: 1-year follow-up
non-cardiac findings on CT
Time frame: 1-year follow-up
downstream testing
Time frame: 1-year follow-up
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.