Platelet Function Analysis in Head Trauma: ASA/Plavix

Chang, Steve S., M.D.97 enrolled

Overview

The investigators are assessing the platelet function analysis of those who sustained significant head trauma while on aspirin or plavix and to assess if any qualitative difference is obtained if platelets are administered.

The platelet function analyzer VerifyNow® P2Y12 uses ADP as agonists to induce platelet activation and ascertain the level of platelet function impaired by these medications. VerifyNow® Aspirin Assay utilizes arachidonic acid as the agonist to measure platelet function specifically along this pathway. Our research question for this study is as follows: Does the administration of desmopressin (DDAVP) and/or the transfusion of platelets in patients with head trauma reverse the platelet inhibition caused by Aspirin and/or Plavix? The investigators hypothesize that with the administration of platelets and/or DDAVP that there is a reversal of the inhibition.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Masking

NONE

Enrollment

Conditions

Head Injury Trauma Blunt

Interventions

PlateletsBIOLOGICAL

1 unit of platelets

DDAVPDRUG

Desmopressin 0.3mcg/kg IV x 1

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age \> 18yrs 2. Must be a trauma patient with blunt head trauma. 3. Must be on Aspirin and/or Plavix 4. Subject or Legally Authorized Representative (LAR) (per Heath and Safety Code, Sections 24170 to 24179.5) must sign study consent within 4 hours from the first blood draw. (If this criterion is not met the initial blood draw must be destroyed and NOT run for study results). Exclusion Criteria: 1. Hemoglobin ≤ 10 GM/DL 2. Platelet Count ≤ 150 K/MCL 3. Pregnant Females 4. Subjects on Warfarin, Heparin or Enoxaparin

Locations (1)

Santa Barbara Cottage Hospital

Santa Barbara, California, United States

Outcomes

Primary Outcomes

Platelet inhibition

We are measuring platelet inhibition using the verify now platelet function analyzer

Time frame: 8 hours

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.