Effect of Mindfulness Training on Sleep and Inflammation Among Older Adults With Sleep Problems

University of California, Los Angeles48 enrolled

Overview

The primary aim of the study is to test the effect of mindfulness training on sleep parameters among older adults with insomnia symptoms The secondary aims are to examine if changes in mindfulness meditation practice (daily log) and level of mindfulness (self-report) are associated with changes in sleep parameters, and to determine if mindfulness training is associated with in vitro biological markers of peripheral inflammation

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Sleep Problems Inflammation

Interventions

Mindfulness MeditationBEHAVIORAL

Participants will attend weekly 2-hour classes for a total of 6 weeks and participants will monitor their sleep with a daily sleep diary.

Sleep EducationBEHAVIORAL

Participants will attend weekly 2-hour classes for a total of 6 weeks and participants will monitor their sleep with a daily sleep diary.

Eligibility

Sex: ALLMin age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Men and women (all races and ethnicities) 55 years of age and older * Have current problems sleeping * Fluent in English * Able to understand and provide signed informed consent * Willing to be randomly assigned to treatment condition Exclusion Criteria: * Individuals currently undergoing major medical treatment such as surgery, radiation, or immunotherapy * Individuals living outside of a 20 mile radius from the UCLA Medical Center * Individuals with current substance dependence

Locations (1)

University of California, Los Angeles

Los Angeles, California, United States

Outcomes

Primary Outcomes

Sleep

Primary sleep outcomes to be assessed include Daily sleep diary, Pittsburgh Sleep Quality Index, Fatigue Symptom Inventory, Insomnia Severity Index, and Pre-Sleep Arousal Scale

Time frame: Within 2 weeks post-intervention

Secondary Outcomes

Mindfulness

Mindfulness will be assessed by self report with the Five Facet Mindfulness Questionnaire and a daily log of amount of mindfulness practice

Time frame: Within 2 weeks post-intervention

Inflammatory Biology

Pro-inflammatory cytokines and associated transcription markers will be assessed with in vitro assay of peripheral blood via venipuncture collected between 9am and 1130am

Time frame: Within 2 weeks post-intervention

Data from ClinicalTrials.gov

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