This trial is conducted in Europe. The aim of this trial is to investigate if liraglutide adjunct to insulin treatment changes the glucagon response during hypoglycaemia in subjects with type 1 diabetes compared with conventional insulin treatment after 4 weeks' treatment with liraglutide or placebo. Subjects will initially be randomised to one of the three dose groups, and subsequently randomly allocated to one of two treatment sequences (liraglutide/placebo or placebo/liraglutide).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
45
Administered subcutaneously (s.c., under the skin) once daily for 4 weeks.
Administered subcutaneously (s.c., under the skin) once daily for 4 weeks.
Novo Nordisk Investigational Site
Graz, Austria
Geometric mean glucagon concentration during hypoglycaemia (nadir glucose (target 2.5 mmol/L) )
Time frame: At week 4
Geometric mean glucagon concentration at plasma glucose levels other than nadir
Time frame: At week 4
Geometric mean concentrations of adrenaline and noradrenaline at nadir
Time frame: At week 4
Time from termination of insulin infusion at nadir to reach plasma glucose 4.0
Time frame: At week 4
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