This study will assess the pharmacokinetics of MK-8931, a ß-secretase inhibitor, in participants with renal insufficiency. In Part 1 of the study, pharmacokinetics of MK-8931 in participants with severe renal disease and in healthy matched control participants will be studied. If data from Part 1 confirms that severe renal impairment does not alter the pharmacokinetics of MK-8931 to the extent requiring dosage adjustment, then no further study will be required and Part 2 will be optional. If the data does not support this conclusion, then Part 2 will be conducted to study the pharmacokinetics of MK-8931 in participants with moderate and mild renal impairment compared to healthy matched controls.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
12
Single dose, administered as oral capsules
Area under the plasma concentration-time curve from time zero to infinity (AUC0-inf) of MK-8931
Time frame: Predose through 120 hours post single dose of MK-8931
Renal clearance (CLr) of MK-8931
Time frame: Predose through 120 hours post single dose of MK-8931
Fraction of MK-8931 dose excreted in urine (fe)
Time frame: Predose through 120 hours post single dose of MK-8931
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