Injectable Collagenase and Percutaneous Needle Fasciotomy for Dupuytren's Contracture

Jeppe Lange, MD50 enrolled

Overview

Comparing injectable collagenase and percutaneous needle fasciotomy for Dupuytren's contracture affecting proximal interphalangeal joints. An open label, medico-independent randomized controlled trial.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Dupuytrens Contracture

Interventions

XiapexDRUG

Collagenase Clostridium Histolyticum

Percutaneous needle fasciotomyPROCEDURE

Percutaneous needle fasciotomy ad modum Lermusiaux and Debeyre

Eligibility

Sex: ALLMin age: 18 YearsMax age: 99 Years

Medical Language ↔ Plain English

Inclusion Criteria: * DC affecting PIP joint with Passive Extension Deficit (PED) more than 20 degrees * Clearly defined strings Exclusion Criteria: * Allergies to used medication * International Normalised Ratio more than 2.0 * Pregnancy and breastfeeding * Previous treatment for DC in affected finger * Former inclusion in the study with another string * Activity in disease at time of study * PED more than 20 degrees for Metacarpophalangeal or Distal Interphalangeal joint in affected digit

Locations (1)

Center for Planned surgery - Regionalhospital Silkeborg

Silkeborg, Denmark

Outcomes

Primary Outcomes

Clinical improvement

Clinical improvement is defined as a contracture reduction 50% or more from baseline.

Time frame: 2 years

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.