Study to Characterize Lung Deposition, Pharmacokinetics, Safety and Tolerability of Single Inhalations of Radiolabeled Ciprofloxacin Dry Powder in Healthy Subjects and Patients With Chronic Lung Diseases

Inclusion Criteria: * Inclusion criteria for all subjects: * Understanding of the study and written informed consent prior to any study-related procedures * Additional inclusion criteria for healthy subjects: * Age: 18 to 65 years (inclusive) at screening visit * Males * Non- or ex-smokers who smoked \< 5 pack-years and stopped smoking \> 1 year prior to screening visit * Results of laboratory tests within the normal ranges; minor deviations are acceptable provided that they are not judged clinically significant by the investigator * Additional inclusion criteria for patients with COPD (chronic obstructive pulmonary disease): * Age: 40 to 70 years (inclusive) at screening visit * Males and females * All patients must have a diagnosis of COPD of Stage II or III according to the GOLD (Global Initiative for Chronic Obstructive Lung Disease) Classification (post-bronchodilator forced expiratory volume in 1 second (FEV1): 80% \> FEV1 ≥ 30% of predicted values and a post-bronchodilator FEV1/FVC ≤ 70% (FVC = forced vital capacity) * Minimum smoking history of 10 pack-years * Additional inclusion criteria for patients with bronchiectasis: * Age: 18 to 75 years (inclusive) at screening visit * Males and females * Diagnosis of bronchiectasis Exclusion Criteria: * Known hypersensitivity, allergy or intolerance to study drug formulation ingredients * Febrile illness within 1 week prior to screening visit * Concomitant severe diseases (judged by the investigator) or diseases which are contraindications for the use of inhaled ciprofloxacin * Use of ciprofloxacin within 30 days before screening visit * Use of systemic or topical medicines or substances which oppose the study objectives or which might influence them, e.g. systemic administration of antibiotics which are subject to renal excretion (e.g. beta-lactam antibiotics, levofloxacin, ofloxacin, etc.), furosemide and antacids * Donation of more than 450 mL of blood within 4 weeks before screening visit * Clinically relevant findings in the ECG * Clinically relevant abnormal laboratory values suggesting an unknown disease and requiring further clinical investigation * Participation in another clinical study less than 8 weeks prior to screening visit * Pulmonary exacerbation within the 6 weeks prior to screening * History of lung transplant or any lung surgery or on any thoracic surgery waiting list * Additional exclusion criteria for healthy subjects * Lung function measurements outside normal limits (Normal values: FEV1/FVC \> 70% and FEV1 and FVC \> 80% of predicted) * Additional exclusion criteria for patients * Regular use of daytime oxygen therapy * Diagnosis of bronchial asthma * Diagnosis of clinically evident bronchiectasis (COPD patients) * Total blood eosinophil count \>/= 600/mm3. * Completion of a pulmonary rehabilitation program in the six weeks prior to screening visit or current participation in a pulmonary rehabilitation program * Change in dose or type of any medications within 4 weeks prior to the screening visit