Effect of Fibrin Sealant on Early Wound Healing

Inclusion Criteria: 1. A subject has to be between the ages of 18 and 60 years. 2. Severe Periodontitis: Presence of a jaw with each quadrant having atleast 4 teeth with a probing depth of ≥ 6mm and is indicated for periodontal flap surgery. 3. Compliance: Only patients with optimal compliance, as assessed during the cause-related phase of therapy, are selected. 4. Good oral hygiene: Full-mouth plaque score (FMPS) \< 25%. 5. Low levels of residual infection: Full-mouth bleeding score (FMBS) \< 25%. 6. Endodontic status: Teeth had to be vital or properly treated with root canal therapy Exclusion Criteria: 1. History of any systemic disease such as diabetes mellitus, osteoporosis, unstable or life-threatening conditions, bleeding disorder, undergoing antibiotic or other antimicrobial therapy. 2. Current or former smokers. 3. Had undergone periodontal therapy in the past 6 months, or exhibit poor plaque control after phase I therapy. 4. Mobility of selected teeth. 5. Pregnant or lactating women.