Hepcidin Levels in Preterm Infants

Meir Medical Center62 enrolled

Overview

A recently isolated peptide hormone, hepcidin, is thought to be the principal regulator of iron homeostasis. Hepcidin acts by limiting intestinal iron absorption and promoting iron retention in reticuloendothelial cells. The aims of this study were to determine serum hepcidin levels in preterm infants who receive blood transfusion and preterm infants having sepsis, in order to assess possible relationships between hepcidin and serum iron, serum ferritin,in iron load situations.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Preterm Infants Anemia of Prematurity Neonatal Sepsis

Eligibility

Sex: ALLMin age: 24 WeeksMax age: 37 Weeks

Medical Language ↔ Plain English

Inclusion Criteria: * Preterm \< 38 weeks gestation * Need of blood test for anemia or suspected sepsis Exclusion Criteria: * Major congenital anomalies * Birth Asphyxia

Locations (1)

Neonatal Intensive Care Unit

Kfar Saba, Israel

Outcomes

Primary Outcomes

Increase in Hepcidin levels by 30%

Time frame: within 24-72 h

Data from ClinicalTrials.gov

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