Sublingual Misoprostol Versus Standard Surgical Care for the Treatment of Incomplete Abortion in Nigeria

Gynuity Health Projects90 enrolled

Overview

Women diagnosed with incomplete abortion in this health facility will be randomized to receive one of the following regimens: 400 mcg sublingual misoprostol in one dose or standard surgical treatment (MVA). The investigators hypothesize that treatment of incomplete abortion with misoprostol using 400 mcg administered sublingually will be as effective as surgical evacuation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Incomplete Abortion

Interventions

MisoprostolDRUG

single dose of 400 mcg misoprostol administered sublingually

surgery Manual vacuum aspiration (MVA)PROCEDURE

standard surgical treatment

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * no contraindications to misoprostol * uterine size was not larger than 12 weeks * there were no signs of severe infection * haemodynamically stable * in general good health * willing to provide contact information Exclusion Criteria: * an IUD in place * ectopic pregnancy * aged below 18 years and had no accompanying adult to provide informed consent

Locations (2)

Adeoyo Maternity Hospital

Ibadan, Nigeria

University College Hospital, Ibadan

Ibadan, Nigeria

Outcomes

Primary Outcomes

Complete abortion without recourse to surgical intervention

Time frame: follow up visit 7 days after initial treatment

Data from ClinicalTrials.gov

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