Study in Healthy Volunteers to Assess Effect of Omeprazole and Ranitidine on the Pharmacokinetics of Vandetanib

Inclusion Criteria: * Provision of signed and dated, written informed consent prior to any study-specific procedures * Volunteers must be males or females aged 18 to 50 years and with a weight of at least 50 kg and body mass index (BMI) between 18 and 30 kg/m2 * Inclusive Females must have a negative pregnancy test at screening and on admission to the study center * Females must not be lactating and must be of non childbearing potential defined as postmenopausal or documentation of irreversible surgical sterilization. Exclusion Criteria: * History of any clinically significant disease or disorder such as gastrointestinal, hepatic, renal or skin disease. * History of severe allergy/hypersensitivity or ongoing allergy/hypersensitivity * Volunteers who smoke more than 5 cigarettes per day or are unable to refrain from smoking while resident in the study center * Screening blood pressure of greater than 140/90 mmHg and/or a resting heart rate of less than 45 beats per minute (repeat test allowed at the Investigator's discretion * Clinically significant abnormal12-lead ECG as assessed by the Investigator * QTcF interval greater than 450 ms Any positive result on screening for serum hepatitis B surface antigen, hepatitis C antibody * Human immunodeficiency virus (HIV), or positive screen for drugs of abuse.