A Study of MCAF5352A in Healthy Volunteers

Inclusion Criteria: * Healthy males and females, 18 - 55 years of age * Subjects in good health as determined by screening medical history, physical examination, vital signs, 12-lead ECG and laboratory tests * Body weight between 45 kg and 110 kg * Female subjects must be willing to use two effective methods of contraception from screening to a minimum of 4 months after the last dose of study drug Exclusion Criteria: * Pregnant or lactating women * Positive for hepatitis B, hepatitis C or HIV infection * History of significant chronic or recurrent infections * History of clinically significant drug allergy and/or a known hypersensitivity to protein therapeutics or formulation components or a related drug * History of alcohol or drug abuse within 12 months prior to Day 1, or evidence of such abuse * Subjects who have previously received the study drug * Participation in a clinical trial within 4 weeks prior to Day 1 or use of any experimental or biologic therapy within 12 weeks prior to Day 1 or within 5 half-lives of the product, whichever is greater