An Exploratory Study to Investigate Bladder Contractions in the Storage Phase and Related Bladder Sensations in Healthy Females and Females With Overactive Bladder (OAB) Using High Resolution and Conventional Urodynamics

Inclusion Criteria: OAB Subjects * Has history of signs and symptoms of OAB including urinary frequency, urgency or urge incontinence for greater than or equal to 3 months * At enrolment visit (V2) the subjects must have: * At least 1 episode of urgency with or without incontinence in the last 3-day micturition diary * Frequency of micturition greater than or equal to 8 per 24 hours period during the 3-day micturition diary period * At the screening visit, the subject should be either naïve to OAB treatment (e.g no prior history of medications to treat lower urinary tract symptoms (LUTS), including OAB) or currently on treatment for LUTS (including OAB) and is willing to undergo a washout period for 3 weeks Main Exclusion criteria: Healthy subjects * History of lower urinary tract symptoms (LUTS), including OAB * History of stress urinary incontinence, urethral sphincter incompetence and neurogenic detrusor overactivity * History of signs or symptoms suggestive of urinary tract infection (confirmed by positive urine analysis) * History of bladder outlet obstruction (not including detrusor-overactivity) for example bladder/vesicouterine pro-lapse (\> grade II) or chronic obstruction * History of urinary tract surgery less than or equal to 6 months prior to screening * Has an indwelling catheter or permanent catheter fitted * History of pelvic area radiotherapy treatment * Uncontrolled diabetes mellitus * History of fibromyalgia * Pregnant or intends to become pregnant during the study or sexually active, of childbearing potential and is unwilling to utilize a reliable method of birth control (note: reliable methods are contraceptive pills of combination type, hormonal implants, injectable contraceptives, sexual abstinence or vasectomized partner) * Pregnancy within 6 months before screening or breast feeding within 3 months before screening * History of a positive hepatitis A, B surface antigen, hepatitis C antibody or HIV test result. * Any use of drugs of abuse within 3 months prior to screening visit. * History of smoking more than 10 cigarettes (or equivalent amount of tobacco) per day within 3 months prior to screening visit * History of drinking more than 14 units of alcohol per week (1 unit = 10 g pure alcohol = 250 ml of beer (5%) or 35 ml of spirits (35%) or 100 ml of wine (12%) within 3 months prior to screening visit * Is currently receiving or has a history of treatment with alpha blockers, beta receptor blockers or agonists, botulinum toxin (less than 12 months), resiniferatoxin or pelvic floor muscle relaxants less than or equal to 9 months prior to screening Main exclusion criteria OAB subjects * Refer to healthy subjects exclusion criteria number 2 to 16