Neuroimaging Study of Bupropion Treatment in Patients With Major Depressive Disorder

Inclusion Criteria: * Men and women aged between 20 and 65 * Diagnosis of major depressive disorder (MDD) as assessed by the Structured Clinical Interview for DSM-IV (SCID-IV) * Individuals who provided written consent for participation. Exclusion Criteria: * Presence of any major physical or neurological illness (e.g., head trauma, epilepsy, seizure, stroke, cerebral tumor, multiple sclerosis, cerebrovascular disease, narrow-angle glaucoma, drug hypersensitivity, etc.) * Diagnosis of any Axis I disorder other than MDD or presence of symptoms requiring hospitalization * Intelligence quotient (IQ) below 80 * Contraindications to magnetic resonance imaging (e.g., pacemaker implantation, claustrophobia, etc.) * Unstable medical illness or other abnormalities observed at the screening or laboratory tests * Women who are pregnant, breastfeeding, or planning pregnancy * Allergy or tolerance to the clinical trial medication * Presence of any physical illness that contraindicates the clinical trial medication (e.g., epilepsy, history of uncontrollable narrow-angle glaucoma) * Use of psychoactive medications that may affect brain imaging findings