The Effect of Mentholyptus Drops on the Palatability of PEG-Electrolyte Solution

American University of Beirut Medical Center99 enrolled

Overview

The investigators aim is to study the efficacy of mentholyptus drops in improving the palatability of PEG-electrolyte solution used in bowel cleansing for colonoscopy. The study is a randomized controlled trial which will include patients undergoing elective colonoscopy at the American University of Beirut Medical Center. Patients will be randomized into one of two study arms using a computer generated randomization list. Patients assigned to the intervention arm will be asked to have candy (Halls®) during the whole 2 hours period while drinking the PEG solution unlike the control arm patients who will only receive the PEG solution. All patients will then be evaluated for the tolerability of the preparation while taking into account the palatability of the solution as main outcome and the remaining volume of the PEG solution and side effects as secondary outcomes.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

NONE

Enrollment

Conditions

Colon Cancer

Interventions

Patients will be instructed to drink 4 Liters of PEG solution (FORTRANS®) split into 2 days while sucking on sugar-free mentholyptus drops (2 L at 7-9 pm on the day prior to the colonoscopy while continuously sucking on Halls®, and 2 L on the day of the colonoscopy to be completed a minimum of 1.5 hours before the procedure while continuously sucking on Halls®)

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * elective colonoscopy * consent to the study Exclusion Criteria: * pregnant or lactating women * age less than 18 years * significant gastroparesis * gastric outlet obstruction * ileus * known or suspected bowel obstruction or perforation * phenylketonuria * glucose-6-phosphate dehydrogenase deficiency * severe chronic renal failure (creatinine clearance \<30 mL/minute) * severe congestive heart failure (NYHA class III or IV) * dehydration * severe acute inflammatory disease * compromised swallowing reflex or mental status * uncontrolled hypertension (systolic blood pressure ≥170 mm Hg, diastolic blood pressure ≥100 mm Hg) * toxic colitis or megacolon * previous colonoscopy within the last 5 years * active Inflammatory bowel disease * previous colectomy or partial colectomy

Outcomes

Primary Outcomes

measurement of Palatability of the PEG-electrolyte solution

patients will be asked to assess the palatability of the colon preparation solution (Fortrans®) by giving it a score on a scale from 1 to 5 with 1 being disgusting and 5 being tasty after drinking the whole solution and immediately prior to the colonoscopy

Time frame: 1.5 hours after drinking the solution

Secondary Outcomes

volume remaining of the colon preparation solution

Patients will be asked to bring with them to the endoscopy suit the volume remaining, if any, of the colon preparation solution that they were not able to drink. The volume remaining will be measured by the research fellow using a graduated cylinder.

Time frame: 1.5 hours after drinking the solution

Side effects

number of patients who experienced nausea, vomiting, bloating, abdominal cramps or headaches while drinking the solution.

Time frame: 1.5 hours after drinking the solution

The Effect of Mentholyptus Drops on the Palatability of PEG-Electrolyte Solution

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes