Studying Biomarkers in Samples From Younger Patients With Wilms Tumor

Children's Oncology Group20 enrolled

Overview

RATIONALE: Studying samples of tissue and urine from patients with cancer in the laboratory may help doctor learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research trial studies biomarkers in samples from younger patients with Wilms tumor.

OBJECTIVES: * To determine a unique molecular "finger print" of primary Wilms tumor arising in ethnically diverse children who are at increased risk to develop this lethal malignancy and subsequently relapse. * To determine a unique protein "finger print" from the urine of ethnically diverse children who develop Wilms tumor and subsequent relapse. OUTLINE: Formalin-fixed paraffin-embedded and snap-frozen primary tissue samples, and urine samples collected at the time of diagnosis and before treatment, are analyzed for molecular and protein profile by MALDI-TOF mass spectroscopy, western blotting, immunohistochemistry, and reverse-transcriptase polymerase chain reaction (RT-PCR) assays.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Kidney Cancer

Interventions

gene expression analysisGENETIC

proteomic profilingGENETIC

reverse transcriptase-polymerase chain reactionGENETIC

western blottingGENETIC

Eligibility

Sex: ALL

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Diagnosed with Wilms tumor * Specimens from African-American and from Caucasian children * Specimens from each ethnicity who relapsed * Specimens from each ethnicity who did NOT relapse PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Outcomes

Primary Outcomes

Molecular "finger print" of primary Wilms tumor in ethnically diverse children

Protein "finger print" from the urine of ethnically diverse children

Data from ClinicalTrials.gov

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