Pilot Feasibility Study of the Safety and Efficacy of Anakinra in Heart Failure With Preserved Ejection Fraction

Inclusion Criteria: * Symptoms and signs of congestive heart failure * Recent Imaging Study (\<12 months) showing Left Ventricular Ejection Fraction (LVEF) \>50% and Left Ventricular End Diastolic Volume Index (LVEDVI) \<97ml/m2 * Evidence of abnormal Left Ventricular (LV) relaxation, filling, diastolic distensibility, and diastolic stiffness as shown by one of the following: 1. Invasive Hemodynamic measurements * mean Pulmonary Capillary Wedge pressure (mPCW) \>12 * Left Ventricular End Diastolic Pressure (LVEDP) \>16 mmHg 2. Tissue Doppler Echocardiogram * E/E' \>15 * E/E' 8-15 and one of the following * Left Ventricular Hypertrophy (LVH) * Atrial Fibrillation * Left Atrial Enlargement * E/A \<0.5 + Deceleration Time (DT) \>280 (if \>50yrs of age) 3. Biomarkers * Brain Natriuretic Peptide (BNP) \>200pg/mL Exclusion Criteria: * Age \<18 * Recent changes (previous 3 months) in HF maintenance medications (beta-blockers, angiotensin converting enzyme \[ACE\] inhibitors, aldosterone antagonists, vasodilators, cardiac glycosides, diuretics) * Hospitalization for worsening Heart Failure (HF) or acute decompensated HF within the previous 12months * Anticipated need for cardiac resynchronization therapy (CRT) or automated-implantable cardioverter defibrillator (AICD) * Angina or electrocardiograph (ECG) changes that limit maximum exertion during cardiopulmonary exercise testing * Active infection including chronic infection * Active cancer * Recent (\<14 days) use of anti-inflammatory drugs (not including Non-Steroidal Anti-Inflammatory Drugs \[NSAIDs\]), Chronic inflammatory disorder (including but not limited to rheumatoid arthritis, systemic lupus erythematosus), malignancy, or any comorbidity limiting survival or ability to complete the study * Pregnancy (determined by urine pregnancy test in women of childbearing potential) * Inability to give informed consent * Other conditions limiting completion of cardiopulmonary exercise test or completion of the study