IL-6 and IL-8 Level of Blood and Pleural Effusion During Chemotherapy in Metastatic Breast Cancer

Inclusion Criteria: * Female between 18 and 70 years old; * Patients with histologic proved metastatic breast cancer; * Pleural effusion with the volume of more than 1000ml, as documented by CT, X ray or ultrasound; * There are no other diseases which cause the elevation of IL-6 or IL-8, such as cirrhosis of liver, anaphylactoid purpura, acute pancreatitis; * With at least one measurable disease according to RECIST criteria, * Normal laboratory results:ANC≥2.0×109/L,Hb≥80g/L,plt≥100×109/L,TB\<UNL (\<1.5 x UNL in patients with liver mets),ALT/AST\< 1.5 x UNL (\<2.5x UNL in patients with liver mets),AKP\<5 x UNL(except bone mets),Cr\<UNL; * Normal functions with heart, liver,renal and bone marrow; * Got ICF before enrollment; * Life expectancy more than 12 weeks. Exclusion Criteria: * Pregnant or breast-feeding women or positive serum pregnancy test; * Uncontrolled brain metastases; * No recovery from previous radiation or accepted radiation within 4 weeks before enrollment; * Participation in any investigational drug study within 4 weeks preceding treatment start; * Concurrent other malignancy at other sites or previous other cancer within the last 5 years, with the exception of adequately treated in situ carcinoma of cervix uteri or basal or squamous cell carcinoma of the skin; * Serious uncontrolled intercurrent infections; * Poor compliance.