Cytidine- and Creatine-Containing Drug in Treating Bipolar Depression

Inclusion Criteria: * 19-65 year-old male or female * Bipolar depression diagnosed by Structured Clinical Interview for DSM-IV (SCID-IV) * Written informed consent Exclusion Criteria: * Present use of drugs for bipolar depression or any psychotropic medication * Use of psychoactive medication that may affect brain imaging findings * Diagnosis of any other axis I psychiatric disorder * Presence of borderline personality disorder or antisocial personality disorder * Presence of any major physical or neurological illness (e.g., epilepsy, multiple sclerosis, brain tumor, cerebrovascular disease, etc.) * Hypersensitivity to divalproate, valpromide or diagnosis of porphyria * Past or current liver disease, current severe liver or pancreas dysfunction * Currently taking mefloquine * Presence of alcohol or drug dependence, drug abuse * Intelligence quotient below 80 * Contraindications to magnetic resonance imaging * Women who are pregnant, breastfeeding, or planning pregnancy * Allergy or intolerance to the study drugs