Effects of Curcumin on Vascular Reactivity

University Hospital, Clermont-Ferrand21 enrolled

Overview

The aim of this study is to determine if an oral loading-dose of curcumin can improve vascular endothelium reactivity in patients with moderate cardiovascular risk

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Healthy Volunteers (Middle-aged Smokers)

Interventions

CurcuminDRUG

The aim of this study is to determine if an oral loading-dose of curcumin can improve vascular endothelium reactivity in patients with moderate cardiovascular risk

Eligibility

Sex: ALLMin age: 50 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 50 to 70 year-old volunteers * smokers Exclusion Criteria: * treated hypertension * treated hypercholesterolemia * chronic disease * vegetarian or other unusual diets * chronic alcoholism

Locations (1)

CHU Clermont-Ferrand

Clermont-Ferrand, France

Outcomes

Primary Outcomes

Changes in brachial Flow Mediated Dilatation

Time frame: at Visit 1 (Day 0) and visit 2 (Day3/day5)

Secondary Outcomes

Changes in fingertip arterial tonometry

Time frame: at visit 1 (day 0) and visit 2 (day3/day5)

Modifications of leukocytes transcriptome

Time frame: at visit 1 (day 0) and visit 2 (day3/day 5)

Data from ClinicalTrials.gov

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