EEG Studies of Induction and Recovery From Propofol Induced General Anesthesia

Massachusetts General Hospital36 enrolled

Overview

The purpose of this study is to investigate how the commonly used anesthetic drug propofol works in the brain to produce loss of consciousness. While under general anesthesia your brain waves will be measured using electroencephalogram (EEG). On a separate day, the patient's brain will be imaged using magnetic resonance imaging (MRI).

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Brain Activity Under Sedation

Interventions

PropofolDRUG

Propofol will be infused using a computer controlled delivery system running the program STANPUMP. Loss of consciousness will be defined as loss of response to auditory stimulus (button press).

Eligibility

Sex: ALLMin age: 18 YearsMax age: 36 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy, non-smoking male and female volunteers, ages 18-36 with normal body weight. * American Society of Anesthesiologists (ASA) physical status I Exclusion Criteria: * History of head trauma * Surgical aneurysm clips * Cardiac pacemaker * Prosthetic heart valve * Neurostimulator * Implanted pumps * Cochlear implants * Metal rods, plates * Screws * Intrauterine device * Hearing aid * Dentures (which might create NMR artifacts) * Metal injury to eyes

Locations (1)

Massachusetts General Hospital

Boston, Massachusetts, United States

Outcomes

Primary Outcomes

EEG Power in Alpha, Slow, and Delta Bands

We used EEG measurements to study the dynamics of loss of consciousness, auditory processing, sensation, and memory under general anesthesia induced with propofol. The EEG data in each of the three specific aims will be analyzed using spectral methods, source localization, and event-related potentials. Through spectral analysis, EEG power (in decibels) in alpha, slow, and delta bands are measured.

Time frame: 11 hours

Data from ClinicalTrials.gov

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