Neurofeedback as a Treatment Tool for Depression

Cardiff University43 enrolled

Overview

The purpose of the study is to investigate whether neurofeedback delivered via functional magnetic resonance imaging signals can be used to train depressed patients to self-regulate emotion networks and whether this improves clinical symptoms.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Unipolar Depression

Interventions

fMRI-based neurofeedbackOTHER

5 sessions lasting one hour each

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * major depressive disorder (MDD) diagnosis * stable antidepressant dose medication Exclusion Criteria: * Other physical or psychiatric disorders * Current substance abuse * Current psychotherapy or other specific intervention * Exclusion criteria applicable to MRI

Locations (2)

CUBRIC

Cardiff, Wales, United Kingdom

School of Medicine, Cardiff University

Cardiff, Wales, United Kingdom

Outcomes

Primary Outcomes

Change from Baseline in Hamilton Depression Rating Scale (HDRS) score at the end of intervention (after 5th session)

Time frame: Before start trial (baseline), after intervention (appr. 2 months)

Secondary Outcomes

Change from Baseline in Hamilton Depression Rating Scale (HDRS) score at follow-up

Time frame: Baseline, 3-month follow-up

Change from Baseline in Hospital Anxiety and Depression Scale (HADS) anxiety score at the end of intervention (after 5th session)

Time frame: Baseline, end of intervention (appr. 2 months)

Change from Baseline in Hospital Anxiety and Depression Scale (HADS) anxiety score at follow-up

Time frame: Baseline, 3-month follow-up

Change from Baseline in Hospital Anxiety and Depression Scale (HADS) depression score at the end of intervention (after 5th session)

Time frame: Baseline, end of intervention (appr. 2 months)

Change from Baseline in Hospital Anxiety and Depression Scale (HADS) depression score at follow-up

Time frame: Baseline, 3-month follow-up

Change from Baseline in the Quality of Life Scale (QOLS) at the end of intervention (after 5th session)

Time frame: Baseline, end of intervention (appr. 2 months)

Change from Baseline in the Quality of Life Scale (QOLS) at follow-up

Time frame: Baseline, 3-month follow-up

Change from Baseline in the European Quality of Life-5 dimensions scale (EQ-5D) at the end of intervention (after 5th session)

Data from ClinicalTrials.gov

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