Plasma Neutrophil Gelatinase Associated Lipocalin Levels During Emergency Management of Rhabdomyolysis

Centre Hospitalier Universitaire de Nīmes197 enrolled

Overview

This research project consists of a prospective diagnostic study conducted on patients with clinical suspicion of rhabdomyolysis admitted to the emergency rooms of the University Hospitals of Nimes, Montpellier, Paris, Nice and Toulon Inter Army Hospital. The main objective of this study is to determine whether the plasma level of Neutrophil Gelatinase Associated Lipocalin (NGAL) may be retained as a predictor of acute renal failure (ARF) occurring within 48 hours after admission for rhabdomyolysis.

The secondary objectives of this are: * to study plasma NGAL levels on admission to the emergency ward as a marker of morbidity and mortality by considering the following factors: duration of hospitalization, need for extracorporeal blood purification, ICU admission, death. * to study the delay between the onset of the proposed cause of rhabdomyolysis and treatment initiation * to study the delay between treatment initiation and the occurrence of ARF.

Study Type

OBSERVATIONAL

Enrollment

197

Conditions

Rhabdomyolysis Acute Kidney Failure

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * The patient must have given his/her informed and signed consent * The patient must be insured or beneficiary of a health insurance plan * Patient hospitalized with Creatine Phospho-Kinase \> 1000 UI/l Exclusion Criteria: * The patient is participating in another study * The patient is in an exclusion period determined by a previous study * The patient is under judicial protection, under tutorship or curatorship * The patient refuses to sign the consent * It is impossible to correctly inform the patient * The patient is pregnant, parturient, or breastfeeding * Chronic renal insufficiency with dialysis * The patient has an acute coronary syndrome * Nephrotoxic medications within 72 hours prior to admission * Need for a procedure involving the injection of iodine * Patient in shock * Occurrence of acute renal failure can be explained by a cause other than rhabdomyolysis.

Locations (5)

CHU de Nîmes - Hôpital Universitaire Carémeau

Nîmes, Gard, France

CHU de Montpellier - Hôpital Lapeyronie

Montpellier, France

CHU de Nice - Hôpital St-Roch

Nice, France

APHP - Groupe Hospitalier Pitié-Salpetrière

Paris, France

Hôpital Interarmées Sainte Anne

Toulon, France

Outcomes

Primary Outcomes

Plasma NGAL level

ng/ml

Time frame: Admittance to the ermergency room (ie at baseline)

Secondary Outcomes

Delay between initiation of treatment and beginning of acute renal failure

meaured in hours

Time frame: Day 2

Delay between cause and treatment

Hours elapsed between proposed cause of rhabdomyolysis and treatment initiation measured in hours.

Time frame: Day 2

Need for extracorporeal blood purification

yes/no

Time frame: Hospital discharge (expected average of 2-3 days)

Patient admitted to ICU?

yes/no

Time frame: Hospital discharge (expected average of 2-3 days)

Length of hospitalization

measured in days

Time frame: Hospital discharge (expected average of 2-3 days)

Patient deceased during hospitalization

yes/no

Time frame: Hospital discharge (expected average of 2-3 days)