Pain Patch Versus Injections in the Treatment of Pain Associated With Shoulder Impingement Syndrome

Inclusion Criteria: * be at least 18 years of age. * have pain associated with shoulder impingement syndrome in a single shoulder (minimum 2-week duration). * have tenderness at the attachment site of the rotator cuff tendons. * have positive Hawkin's and Neer's signs. * report an average pain intensity score of 4 (on an 11-point scale) over the past 24 hours at the Screening/Baseline visit. Exclusion Criteria: * have used any topically applied pain medication on the target treatment area within 14 days preceding Study Day 1, such as non-steroidal anti-inflammatory drugs (NSAIDs), menthol, methyl salicylate, local anesthetics (including Lidoderm®), or steroids. * have used any injected medication within 60 days preceding Study Day 1, such as local anesthetic (lidocaine) or steroids. * have a clinically significant illness within 14 days of Screening/Day 1 that, in the opinion of the investigator, would preclude the subject from participating in the study. * are receiving class 1 antiarrhythmic drugs (ie, tocainide, mexiletine, etc.) * have a history of and/or past diagnosis of severe hepatic disease. * have participated in a clinical trial of an unapproved drug within 30 days prior to screening. * are pregnant, breastfeeding, or a female of childbearing potential and not practicing an acceptable method of birth control. * are unable or unwilling, in the opinion of the investigators, to comply with all study procedures and cooperate fully with research staff. * have filed a disability claim or are currently receiving disability payments for shoulder impingement syndrome.