Studying Biomarkers in Samples From Young Patients With Rhabdoid Tumors

Children's Oncology Group50 enrolled

Overview

RATIONALE: Studying samples of tissue from patients with rhabdoid tumors in the laboratory may help doctor learn more about changes that occur in DNA and identify genes related to cancer. PURPOSE: This research trial studies biomarkers in samples from young patients with rhabdoid tumors.

OBJECTIVES: * To investigate the expression and function of transposons in 50 primary rhabdoid tumors. OUTLINE: Freshly frozen rhabdoid tumors will be studied using fluorescence in situ hybridization (FISH) and polymerase chain reaction (PCR) to establish the genomic location of transposons. Protein expression in rhabdoid tumor tissue microarrays is also analyzed.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Kidney Cancer

Interventions

DNA analysisGENETIC

fluorescence in situ hybridizationGENETIC

gene expression analysisGENETIC

gene mappingGENETIC

Eligibility

Sex: ALLMax age: 1 Year

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Freshly frozen rhabdoid tumors from either renal or extra-renal sites from children younger than 2 years of age * Clinical patient information (age, gender, comorbidities, tumor stage, size, pathology, therapy, outcome) available PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Outcomes

Primary Outcomes

Expression and function of transposons in rhabdoid tumors

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.