Antimicrobial Catheter Securement Dressings for the Prevention of Cvc-related Bloodstream Infections in Cancer Patients

Inclusion Criteria: * Patients receiving a central venous catheter for chemotherapy of AML or ALL * Patients receiving a central venous catheter for high-dose chemotherapy with consecutive autologous stem cell transplantation or any other condition with an expected duration of chemotherapy-associated neutropenia of at least 5 days and an expected duration of central venous catheter use of at least 10 days * Age \>= 18 years Exclusion Criteria: * Condition with an expected duration of chemotherapy-associated neutropenia of at less than 5 days and an expected duration of central venous catheter use of less than 10 days * Use of a central venous catheter with antimicrobial coating other than chlorhexidine and/or silver-sulfadiazine * Limited venous status, impeding acquisition of peripheral blood cultures in case of febrile neutropenia * Patients previously enrolled in the study * Tunneled central venous catheters * Shaldon catheters * CVC insertion via the V. femoralis * Fever (T \> 37.8°C) related to a suspected or confirmed bacterial infection at randomization * Known allergic/hypersensitivity reaction to any compounds of the treatment * Legal incapacity or limited legal capacity * Medical or psychological condition which in the opinion of the investigator would not permit the patient to complete the study or sign meaningful informed consent