A commonly administered conservative non-pharmacological treatment for OA is exercise, with beneficial effects in terms of reduced pain and disability. While the link between exercise and reduced disability is mediated by e.g. increased muscle strength and endurance, the analgesic mechanisms related to exercise are unexplored. knee OA patients have both peripheral and central sensitization of pain mechanisms resulting in hyperalgesia. Thus, targeted pain treatment in these patients may focus on both peripheral and central mechanisms but it unknown if exercise affects either of these mechanisms. It is hypothesized that in knee OA patients exercise reduces the pain sensitivity
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
60
Physiotherapy supervised exercise training. 60 minutes 3 times per week
The Parker Institute, Dept of rheumatology, Frederiksberg hospital
Copenhagen, Denmark
Change from baseline in mechanical pain sensitivity
Pain thresholds and temporal summation of pain
Time frame: Baseline and at 12 weeks
Change from baseline in proinflammatory cytokines and biomarkers of cartilage breakdown in blood and urine
Time frame: Baseline and at 12 weeks
Change from baseline in patient reported pain and function
KOOS questionnaire
Time frame: Baseline and at 12 weeks
Change from baseline in functional pain test
Pain is assessed during continuous tradmill walking at self-selected pace for 20 minutes.
Time frame: Baseline and at 12 weeks
Change from baseline in imaged based quantification of inflammation in the knee
Contrast enhanced MRI imaging used to quantify inflammation (DYNAMICA software)
Time frame: Baseline and at 12 weeks
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