The purpose of this project is to develop and evaluate Internet-based Cognitive Behavioral Therapy (ICBT) for Parkinson's Disease (PD) patients with concurrent depression or anxiety symptoms. All treatment in this project is given as an adjunct to Standard Medical Treatment (SMT). ICBT will be compared to an Internet-based active control treatment (ICONTROL) and to SMT alone. It is hypothesized that both active treatments will be superior to SMT, and that ICBT will be superior to ICONTROL, in reducing symptoms of depression and anxiety.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
150
12 weeks of Internet-based Cognitive Behavioral Therapy with a focus on behavioral activation
12 weeks of Internet-based treatment with a focus on relaxation training
Internetpsykiatrienehten (Internet Psychiatry Unit), Psykiatri Sydväst, SLSO
Stockholm, Sweden
Change (from baseline) in HADS
Hospital Anxiety and Depression Scale - self rating, to measure anxiety and depression
Time frame: 12 weeks (Post), 3 and 6 months (FU)
Change (from baseline) in MADRS-S
Montgomery and Asberg Depressions Rating Scale - Self report, to measure level of depression
Time frame: 12 weeks (Post), 3 and 6 months (FU)
Change (from baseline) in ISI
Insomnia Severity Index - self-report, to measure insomnia symptoms
Time frame: 12 weeks (Post), 3 and 6 months (FU)
Change (from baseline) in PDQ-8
The Parkinson's Disease Questionnaire-8, to measure various health aspects specific for PD patients
Time frame: 12 weeks (Post), 3 and 6 months (FU)
Change (from baseline) in EQ-5D
EQ-5D, to measure general health and quality of life
Time frame: 12 weeks (Post), 3 and 6 months (FU)
Change (from baseline) in SDS
Sheehan Disability Scale, to measure everyday level of functioning
Time frame: 12 weeks (Post), 3 and 6 months (FU)
Change (from baseline) in NMSQuest
Non-Motor Symptoms Questionnaire, to measure the non-motor symptoms in PD
Time frame: 12 weeks (Post), 3 and 6 months (FU)
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