An prospective / retrospective multicenter observational study whose objectives are to understand the interactions between hepatitis c virus and Non Hodgkin lymphomas. The characteristics , evolution and treatment of diseases will be observed from the study.
Main objectives are: * Description of the clinical and histological characteristics, treatment and evolution of these NHL. * Study their physiopathology by immunological, virologic and molecular studies. The study included prospective or retrospective patients with B- Cell Non-Hodgkin lymphomas (NHL) associated with chronic hepatitis C. The patients are diagnosed or in remission of lymphoma, in relapse or failure of treatments. The enrolment period is 6 years and the total study lasts 8 years. * "Prospective patients" are followed every 6 months during one year, and all the years during 2 or 5 years. * "Retropective patients" are followed all the years during 2 or 5 years. At each follow-up, a blood sample of 50ml is withdrawn allowing ancillary studies. The enrollment is estimated at 140 patients.
Study Type
OBSERVATIONAL
Enrollment
138
Hôpital Necker
Paris, France
presentation of NHL and HCV infection, and treatments of NHL and HCV infection
the presentation of NHL and HCV infection is done by clinical,histological and biological characteristics
Time frame: at the first visit (Day 0)
Summary of intercurrents biological and clinical events
Time frame: Month 6, Month 12, Month 24, Month 36, Month 48 and Month 60
virological response
HCV quantitative viral load
Time frame: Month 60
haematological response
to evaluate the correlation between hematological and virological response
Time frame: Month 60
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