The purpose of this prospective, randomized, double-blind, placebo-controlled study is to evaluate the effect of preoperative administration of alprazolam on the success of the IAN block for teeth with irreversible pulpitis.
Sixty patients diagnosed with irreversible pulpitis of a mandibular molar randomly receive, in a double-blind manner, identical capsules of either 0.50 mg alprazolam or placebo 45 minutes before the administration of a conventional IAN block. Access is begun 15 minutes after completion of the IAN block, and all patients profound lip numbness. Success is defined as no or mild pain based on visual analog scale recordings during access preparation and initial instrumentation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
60
preoperative administration of an orally 0.50 mg single dose
placebo capsules were filled with starch
School of Dentistry, Isfahan University of Medical Sciences
Isfahan, Isfahan, Iran
School of Dentistry, Isfahan University of Medical Sciences
Isfahan, Isfahan, Iran
the success rate of the IAN block
Time frame: one hour after administration of alprazolam
initial pain
Time frame: one hour after administration of alprazolam
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