The purpose of the study is to investigate the effect of a 30 hour cognitive remediation program for young patients with early phase schizophrenia spectrum disorders on cognitive, clinical and functional outcome measures. The remediation program is integrated with whatever active rehabilitation the participant is currently attending (school, work, day program etc).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
50
Cognitive remediation including feedback from neurocognitive assessment, psychoeducation about cognitive deficits, 30 hours of computer based drill and practise and strategy coaching based cognitive remediation, 1-3 collaborative meetings with cognitive specialist, participant, therapist and teacher, occupational therapist or other therapist (depending on participants rehabilitation situation) to enhance transfer of skills to daily functioning
Psychosis Research Unit, Division of Mental Health and Addiction, Oslo University Hospital.
Oslo, Norway
RECRUITINGMATRICS Consensus Cognitive Battery (MCCB)
Included in the MCCB are measures of the following cognitive domains: Speed of Processing, Attention, Working memory, Verbal learning, Visual Learning, Reasoning and problem solving and Social Cognition. In addition the following tests are included: HVLT-R and BVMT-R delayed recall to measure memory, TMTB (Halstead Reitan) and Color Word Inteference Test (D-KEFS) to measure executive functioning), Digit span (WAIS-III)to measure working memory, Grooved Pegboard (Halstead Reitan) to measure motor function.
Time frame: Change in MCCB performance from baseline to 4 months and 9 months
UCSD Performance Based Skilled Assessment Brief Version (UPSA-B)
Time frame: Change in UPSA-B performance from baseline to 4 months and 9 months
Cognitive Assessment Interview (CAI)
Time frame: Change in CAI scores from baseline to 4 months and 9 months
Social Functioning Scale (SFS)
Time frame: Change in SFS scores from baseline to 4 months and 9 months
Calgary Depression Scale
Time frame: Change in CDS scores from baseline to 4 months and 9 months
Global Assessment of Function (GAF)- split version
Time frame: Change in GAF scores from baseline to 4 months and 9 months
event related fMRI
Event-related fMRI will be performed to measure neuronal activity during a spatial working memory tasks and an executive planning task. All fMRI data will be collected on Ullevål's 3 T General Electric Sigma HDx scanner.
Time frame: Change in BOLD fMRI signal from baseline to 4 months
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Rosenberg Self-Esteem Scale (RSES)
Time frame: Change in RSES scores from baseline to 4 months and 9 months