From Acute to Chronic Postoperative Pain in Patients for Elective Cholecystectomy. Immunological Tests

Odense University Hospital18 enrolled

Overview

Chronic Pain after Cholecystectomy is a well known problem. One theory is that it is due to persisting inflammation. The purpose of the study is to measure inflammatory factors in cerebrospinal fluid and blod at patients 12 months after the operation. DNA-samples are collected to examine genetical factors, important for perception of pain, and the development of chronic pain.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Pain

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Group 1: Inclusion Criteria: * Unexplained abdominal pain 12 months after elective cholecystectomy Exclusion Criteria: * Immunosuppressive treatment (NSAID excepted) * Anticoagulant treatment Group 2: Inclusion Criteria: * No pain 12 months after elective cholecystectomy Exclusion Criteria: * Immunosuppressive treatment (NSAID excepted) * Anticoagulant treatment Group 3: Inclusion Criteria: * Elective operation in spinal anesthesia or * Or healthy volunteers accepting samples of blod, cerebral spinal fluid and saliva, to be collected Exclusion Criteria: * Acute or chronic pain condition * Immunosuppressive treatment (NSAID excepted) * Previous abdominal operation

Locations (2)

Odense University Hospital

Odense, Denmark

Lillebælt Hospital

Vejle, Denmark

Outcomes

Primary Outcomes

Spinal interleukine levels

12 months after surgery

Time frame: 12 months

Secondary Outcomes

Blood interleukine levels

Time frame: 12 Months

spinal enzyme levels

12 months after surgery

Time frame: 12 months

Blood enzyme levels

12 months after surgery

Time frame: 12 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.