Single Cohort 4-period Study to Assess Pharmacokinetics of Metformin Alone and in Combination With Ranolazine

Inclusion Criteria: * Males and females, 30 to 65 years old, inclusive * Documented history of T2DM * HbA1c = 6.5%-10%, inclusive * Fasting serum glucose ≤ 270 mg/dL at Screening * Fasting C-peptide ≥ 1 ng/mL at Screening * Stable metformin monotherapy (metformin 1000 to 2000 mg total daily dose for at least 4 weeks prior to Screening) * Body mass index (BMI) = 25 to 40 kg/m2, inclusive, at Screening * Creatinine Clearance \> 80 mL/min at Screening * Females of child-bearing potential must have a negative serum pregnancy test at Screening and a negative urine pregnancy test on Day -1 and must agree to use highly effective contraception methods from Screening throughout the duration of the Treatment Period and for 14 days following the last dose of study drug Exclusion Criteria: * Type 1 Diabetes Mellitus (T1DM) * Use of insulin therapy \< 3 months prior to Screening * History of ketoacidosis, ketosis-prone diabetes, or lactic acidosis * Clinically significant complications of diabetes * History of hypoglycemia * Any non-insulin antidiabetic therapy (other than metformin) \< 2 months prior to Screening * Any clinically significant cardiovascular event \< 2 months prior to Screening * Clinically significant, inadequately controlled, or unstable hypertension * Hospitalization \< 2 months prior to Screening or major surgery \< 3 months prior to Screening * History of gastrointestinal disease or surgery that could impact drug absorption * History of substance of alcohol or substance abuse * Positive urine drug screen for drugs of abuse * Positive alcohol breath test * Any other clinically significant existing medical or psychiatric condition or one requiring further evaluation * Treatment with selected medications * Hemoglobin \< 12 g/dL for males; or \< 11 g/dL for females at Screening * Active thyroid disease (hypo- or hyperthyroidism) * Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \> 2.5x upper limits of normal * QTc interval \> 500 msec at Screening * Females who are pregnant or are breastfeeding