Platelet Reactivity and MES During CEA

UMC Utrecht200 enrolled

Overview

The purpose of this study is to analyze the association between aspirin efficacy and general platelet reactivity in relation to microembolic signals (MES) during carotid endarterectomy (CEA).

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Carotid Artery Stenosis Ischemic Stroke Myocardial Infarction Aspirin Resistance

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Al patients undergoing elective carotid endarterectomy Exclusion Criteria: * Patients requiring a blood transfusion prior to surgery * Patients with an inappropriate temporal bone window for transcranial Doppler (TCD) * Patients on vitamin K antagonists or antiplatelet treatment other then aspirin * Patients with an artificial cardiac valve

Locations (1)

UMC Utrecht

Utrecht, Utrecht, Netherlands

Outcomes

Primary Outcomes

Microembolic signals (MES)

Microembolic signals detected by transcranial duplex (TCD)

Time frame: During and 1 hour following carotid endarterectomy (CEA)

Secondary Outcomes

Ischemic stroke

Time frame: within 30 days postoperative

Asymptomatic perioperative myocardial injury

Troponin elevation \> 0.1 ng/ml

Time frame: 3 days postoperative

Myocardial infarction

Time frame: Within 30 days postoperative

Data from ClinicalTrials.gov

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