Long-term Efficacy of Iguratimod Alone or Iguratimod in Combination With Methotrexate in Patients With Rheumatoid Arthritis

Inclusion Criteria: * Subjects with a diagnosis of RA according to the diagnostic criteria of the American College of Rheumatology (ACR) (revised in 1987) * Rheumatoid Arthritis for 3 months to 2 years from the time of the initial diagnosis * Subjects have active RA at the time of screening * Subjects are naive to MTX or RA related biologics * Written informed consent Exclusion Criteria: * Preceding treatment with DMARDs, immunosuppressants (cyclophosphamide, cyclosporine, azathioprine, etc.), or Tripterygium within 4 weeks prior to study entry * Chest x-ray abnormalities, such as tuberculosis, interstitial pulmonary fibrosis, etc. * ALT \>1.5×ULN, AST \>1.5×ULN, Cr \>135umol/L * WBC\<4×109/L，HGB\<85g/L，PLT\<100×109/L * Subjects with serious cardiovascular, renal, hematologic or endocrine diseases * Pregnant or lactating women * Allergic to any of the study drugs * History of alcoholism * Subjects with mental illness * Subjects receiving live vaccines recently * Subjects participating in other clinical study within 3 months prior to study entry