The purpose of this study is to determine whether short-term Atorvastatin can increase the immunity response to hepatitis B vaccination in vaccine Nonresponders.
20 person of vaccinated individuals who have HBsAb\<10 after 3 dose hepatitis B vaccination who called Nonresponders will be randomly allocated in 2 groups. one group receive short-term Atorvastatin and other group receive placebo.both group will be vaccinated with hepatitis B vaccine and then immunity response will be measured.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
52
one 40 mg Atorvastatin tablet orally per day for 10 days
one Placebo tablet orally per day for 10 days
Baqiyatallah University of Medical Sciences
Tehran, Tehran Province, Iran
Change from baseline in serum HBsAb level
HBsAb level in serum measurement with quantitative ELIZA method
Time frame: 1 month after vaccination
IL-4 level in WBC culture
IL-4 level measurement with polymerase chain reaction method
Time frame: 1 month after vaccination
IL 17 level in WBC culture
IL 17 level measurement with polymerase chain reaction method
Time frame: 1 month after vaccination
TGF-beta level in WBC culture
TGF-beta level measurement with polymerase chain reaction method
Time frame: 1 month after vaccination
IFN-gamma level in WBC culture
IFN-gamma level measurement with polymerase chain reaction method
Time frame: 1 month after vaccination
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