A Randomised Study of Docosahexaenoic Acid (DHA) in Metastatic Breast Cancer

Inclusion Criteria: * Metastatic breast cancer requiring first-line taxanes or anthracyclines based chemotherapy * HER2 negative, HR positive * Life expectancy \> 3 months * ECOG Performance Status \< or = 2 within 15 days before randomization * Measurable and/or evaluable disease according to RECIST criteria 1.1 * Age \> or = 18 years and \< or = 80 years * Body Mass Index (BMI)\>17 for patients \< 70 years and BMI\>21 for patients \> 70 years, within 15 days before randomization * Hepatic parameters : total bilirubin strictly normal, AST and ALT \< or = 3xULN (5 if liver metastases) within 15 days before randomization * Signed written informed consent Exclusion Criteria: * Triple negative breast cancer or HER2 over expression * Symptomatic central nervous system metastases * Previous chemotherapy for metastatic breast cancer * Obesity with BMI \> 35 within 15 days before randomization * Presence of another invasive cancer * Uncontrolled Cardiac disease or uncontrolled hypertension * Milk protein intolerance * Known food allergy to fish * Women of childbearing potential not using adequate contraceptive measures, pregnant or breast feeding.