IPI-145 Single Ascending, Multiple Ascending, Food Effect and Drug-Drug-Interaction Study

Inclusion Criteria: 1. Gender : male or female 2. Age : 18-55 years, inclusive 3. Body Mass Index (BMI) : 18.0-30.0 kg/m2 4. Medical history without major pathology 5. For males only: Willingness to use adequate contraception from the time of dosing and not donate sperm until 3 months after the follow-up visit 6. Females who have a negative pregnancy test at screening and on each admission, and are of non-childbearing potential. Females of non-childbearing potential are defined as women who are surgically sterile or post-menopausal (defined as at least 1 year post cessation of menses and follicular stimulating hormone (FSH) \>23.0 mIU/mL) 7. Willing and able to sign the written Informed Consent Form (ICF) Exclusion Criteria: 1. Previous participation in the current study 2. Evidence of clinically relevant pathology 3. History of relevant drug and/or food allergies 4. Part 4 only: Known or suspected adverse reaction or contraindication to the imidazole class of drugs