A Randomized, Double Blind, Placebo Controlled Trial L-carnitine and Piracetam in the Treatment of Weakness, Muscle Fatigue and Muscle Pain in the Postpoliomyelitis Syndrome

Inclusion Criteria: * Patients with Postpoliomyelitis Syndrome diagnosis confirmed over a year; * Electromyography test compatible with poliomyelitis; * Preserved ability to swallow medication; * Oral communication ability preserved; * Preserved ability to perform pedaling test in at least one lower limb affected by Postpoliomyelitis Syndrome; * Ability to understand information about the study and to document the decision about participating in the trial by signing the Informed Consent Form. Exclusion Criteria: * History of intolerance to L-carnitine or piracetam; * Treatment with L-carnitine during the past 3 months; * Treatment with piracetam or any other nootropics pyrrolidone derivatives, during the past three months; * Anemia (hemoglobin reference range - men 13 to 17 g/dL and women 12 to 15 g/dL); * High level of glycated hemoglobin (\> 7.0%); * Electrolyte imbalance (hypokalaemia - reference potassium concentration range: 3.5 to 5.6 mmol / L); * Renal failure (creatinine reference range: 0.70 to 1.50 mg/dL); * Urinary tract infection; * Thyroid dysfunction (reference range: free T4: 0.54 to 0.67 mg/dL and TSH reference range: 0.5 to 5.5 μUI/mL) or usual treatment with thyroid hormone supplementation; * Cardiomyopathy; * Uncontrolled hypertension; * Known or suspected autoimmune disease; * Confirmed pregnancy, or plans to get pregnant during the trial; * Depression or bipolar affective disorders with moderate to severe episodes within the last twelve months; * Insulin-dependent diabetes mellitus; * Treatment with anticoagulant drugs over two weeks (including non-steroidal anti-inflammatory drugs (NSAIDs), warfarin, phenprocoumon, heparin); * Usual cocaine or alcohol use; * Any other condition judged by the investigator as a possibility to interfere on the participant's decision to be part of the study or to accomplish investigation procedures.