Extended Rhythm SCreening for AtRial Fibrillation in Cryptogenic Stroke Patients

Medisch Spectrum Twente4 enrolled

Overview

Recent studies demonstrated that prolonged rhythm observation increases the detection of atrial fibrillation in patients prior diagnosed as cryptogenic stroke. Detection of atrial fibrillation in these patients has important therapeutic implications for the anticoagulation regimen. However, data on optimal monitoring duration and method of AF detection are limited.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Atrial Fibrillation Stroke

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients \> 18 years of age Recent episode (≤60 days) of cryptogenic ischemic stroke * Undetermined etiology with negative evaluation (including cardioembolism work- up) according to the criteria for the Trial of Org 10172 in Acute Stroke Treatment (TOAST) * Implantation of an implantable loop recorder within two months after index event * Able of providing informed consent Exclusion Criteria: * Pre-existing indication for vitamin K antagonist * Untreated hyperthyroidism * Indication for pacemaker implantation, implantable cardioverter defibrillator (ICD) or Cardiac Resynchronisation Therapy (CRT) * Severe co-morbidity not likely to complete follow-up for one year

Locations (1)

Medisch Spectrum Twente / Thoraxcenter

Enschede, Overijssel, Netherlands

Outcomes

Primary Outcomes

Documented Atrial Fibrillation (AF)

The percentage of patients with documented AF based on implantable cardiac monitor registration during a follow-up period of at least 12 months after an episode of cryptogenic stroke.

Time frame: One year

Secondary Outcomes

Time to documented AF

Time to documented AF using an Implantable Loop Recorder (ILR) data

Time frame: One year

Recurrent stroke

Incidence of recurrent stroke

Time frame: One year

Data from ClinicalTrials.gov

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