Biomarkers in Urine Samples From Patients With Wilms Tumor

Children's Oncology Group100 enrolled

Overview

RATIONALE: Studying samples of urine from patients with cancer in the laboratory may help doctors identify biomarkers related to cancer. PURPOSE: This clinical trial studies biomarkers in urine from patients with Wilms tumor.

OBJECTIVES: * To validate the prognostic performance of specific-candidate Wilms tumor markers by measuring their urinary concentration using enzyme-linked immunosorbent assays (ELISAs) in urine specimens collected at diagnosis from 50 patients with favorable histology Wilms tumor who relapsed and 50 patients who did not relapse. OUTLINE: Urine specimens are analyzed using enzyme-linked immunosorbent assays (ELISAs) for biomarkers.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Kidney Cancer

Interventions

proteomic profilingGENETIC

enzyme-linked immunosorbent assayOTHER

laboratory biomarker analysisOTHER

medical chart reviewOTHER

Eligibility

Sex: ALLMax age: 120 Years

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Urine specimens collected at diagnosis will be selected from patients with stage II-III Wilms tumors, with both local and non-local sites of disease relapse * Clinical patient information (urinalysis/macro, age, gender, congenital defects/syndromes, comorbidities, tumor stage, size, pathology, therapy, outcome) available PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Outcomes

Primary Outcomes

Wilms tumor biomarkers identified by ELISA

Data from ClinicalTrials.gov

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